The double-layer glass reaction vessel is designed with double-layer glass. The inner layer is filled with reaction solvent for stirring reaction, and the interlayer can be connected to different cold and heat sources (freezing liquid, hot water or hot oil) for high-temperature reaction (equipped with corresponding circulating oil bath, temperature can reach 300 ℃) or low-temperature reaction (equipped with corresponding low-temperature freezing liquid circulation system, temperature can reach -80 ℃). Alternatively, a heating and cooling integrated circulation machine can be selected; Under constant temperature conditions, the stirring reaction can be carried out in a closed glass reactor under normal pressure or negative pressure according to usage requirements, and the reaction solution can be refluxed and distilled. During use, it can be evacuated to achieve vacuum reaction. It is an ideal pilot and production equipment for modern fine chemicals, biopharmaceuticals, and new material synthesis. Its design makes the experiment safer and more convenient.